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Zhiyuan Zhong Selected Research

Maytansine (Maitansine)

10/2022Cetuximab-Polymersome-Mertansine Nanodrug for Potent and Targeted Therapy of EGFR-Positive Cancers.
10/2017αvβ3 Integrin-targeted reduction-sensitive micellar mertansine prodrug: Superb drug loading, enhanced stability, and effective inhibition of melanoma growth in vivo.
7/2017cRGD-installed docetaxel-loaded mertansine prodrug micelles: redox-triggered ratiometric dual drug release and targeted synergistic treatment of B16F10 melanoma.
1/2017αvβ3 integrin-targeted micellar mertansine prodrug effectively inhibits triple-negative breast cancer in vivo.
11/2016Glutathione-Sensitive Hyaluronic Acid-SS-Mertansine Prodrug with a High Drug Content: Facile Synthesis and Targeted Breast Tumor Therapy.

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Zhiyuan Zhong Research Topics

Disease

131Neoplasms (Cancer)
11/2022 - 06/2007
22Breast Neoplasms (Breast Cancer)
10/2022 - 05/2011
16Lung Neoplasms (Lung Cancer)
01/2022 - 06/2015
13Hepatocellular Carcinoma (Hepatoma)
01/2021 - 08/2011
12Glioblastoma (Glioblastoma Multiforme)
11/2022 - 12/2014
11Melanoma (Melanoma, Malignant)
10/2022 - 01/2017
7Glioma (Gliomas)
01/2022 - 12/2014
7Multiple Myeloma
10/2021 - 11/2017
5Ovarian Neoplasms (Ovarian Cancer)
01/2022 - 01/2018
4Triple Negative Breast Neoplasms
01/2022 - 01/2017
4Brain Neoplasms (Brain Tumor)
10/2021 - 01/2018
3Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
01/2022 - 01/2018
3Neoplasm Metastasis (Metastasis)
01/2022 - 04/2019
3Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
10/2021 - 10/2017
3Body Weight (Weight, Body)
01/2021 - 01/2017
3Colorectal Neoplasms (Colorectal Cancer)
10/2020 - 11/2018
3Liver Neoplasms (Liver Cancer)
10/2020 - 03/2015
3Myocardial Infarction
01/2017 - 04/2007
2Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
10/2022 - 07/2022
2Carcinoma (Carcinomatosis)
10/2022 - 01/2019
2Bites and Stings (Sting)
10/2022 - 01/2022
2Inflammation (Inflammations)
02/2022 - 01/2015
2Leukemia
10/2021 - 10/2017

Drug/Important Bio-Agent (IBA)

53Pharmaceutical PreparationsIBA
11/2022 - 05/2011
36MicellesIBA
01/2022 - 10/2009
33Peptides (Polypeptides)IBA
01/2022 - 07/2013
33Doxorubicin (Adriamycin)FDA LinkGeneric
01/2021 - 01/2009
24Proteins (Proteins, Gene)FDA Link
11/2021 - 04/2007
23Hyaluronic Acid (Hyaluronan)IBA
10/2021 - 06/2014
14LigandsIBA
01/2022 - 10/2013
14Ethylene Glycol (Monoethylene Glycol)IBA
10/2021 - 08/2011
12ProdrugsIBA
01/2022 - 05/2011
12IntegrinsIBA
01/2021 - 12/2014
11DisulfidesIBA
01/2022 - 02/2017
11NanogelsIBA
04/2019 - 05/2011
10Small Interfering RNA (siRNA)IBA
01/2022 - 04/2007
8PolymersIBA
01/2022 - 04/2007
8Docetaxel (Taxotere)FDA Link
01/2021 - 07/2017
7Paclitaxel (Taxol)FDA LinkGeneric
01/2022 - 03/2010
7caprolactoneIBA
01/2017 - 08/2011
7Galactose (Galactopyranose)FDA LinkGeneric
09/2015 - 08/2011
6cyclic arginine-glycine-aspartic acid peptideIBA
11/2019 - 06/2014
5Maytansine (Maitansine)IBA
10/2022 - 11/2016
5ErbB Receptors (EGF Receptor)IBA
10/2022 - 07/2017
5Glutathione (Reduced Glutathione)IBA
10/2022 - 11/2016
5Granzymes (Granzyme)IBA
01/2022 - 06/2015
5Folic Acid (Vitamin M)FDA LinkGeneric
01/2022 - 06/2014
5Apolipoproteins E (ApoE)IBA
01/2022 - 11/2018
5Transferrin (beta 2 Transferrin)IBA
10/2021 - 06/2014
5Liposomes (Liposome)IBA
01/2018 - 10/2012
5liposomal doxorubicin (Doxil)FDA Link
01/2018 - 10/2016
5polyethylene glycol bis(succinimidyl succinate)IBA
01/2017 - 08/2013
4CytokinesIBA
01/2022 - 01/2015
4Immunoconjugates (Immunoconjugate)IBA
12/2021 - 11/2018
4DNA (Deoxyribonucleic Acid)IBA
10/2021 - 06/2010
4Biological ProductsIBA
10/2021 - 01/2018
4Thioctic Acid (Lipoic Acid)IBA
11/2020 - 05/2015
4Cytochromes c (Cytochrome c)IBA
10/2020 - 08/2016
4AcidsIBA
01/2018 - 08/2013
4HydrogelsIBA
07/2016 - 08/2007
3Vincristine (Oncovin)FDA LinkGeneric
10/2022 - 10/2021
3acetyl- lysyl- prolyl- seryl- seryl- prolyl- prolyl- glutamyl- glutamic acid amideIBA
01/2022 - 01/2020
3Therapeutic UsesIBA
01/2022 - 06/2007
3ApolipoproteinsIBA
01/2022 - 11/2018
3EnzymesIBA
10/2021 - 01/2018
3Oncogene Proteins (Oncogene Protein)IBA
10/2021 - 12/2018
3Nucleic AcidsIBA
10/2021 - 05/2011
3SaporinsIBA
01/2020 - 07/2018
3GE11 peptideIBA
01/2020 - 12/2017
3IodineIBA
11/2019 - 01/2019
3Cell-Penetrating PeptidesIBA
01/2019 - 01/2018
3Methotrexate (Mexate)FDA LinkGeneric
01/2018 - 09/2015
3Matrix Metalloproteinases (MMPs)IBA
10/2017 - 01/2017
3Glutamic Acid (Glutamate)FDA Link
11/2016 - 09/2015
2Pemetrexed (MTA)FDA Link
10/2022 - 01/2018
2Monoclonal AntibodiesIBA
10/2022 - 10/2019
2Interleukin-6 (Interleukin 6)IBA
02/2022 - 10/2021
2Cancer VaccinesIBA
01/2022 - 10/2021
2CPG-oligonucleotideIBA
01/2022 - 01/2022
2Biocompatible Materials (Biomaterials)IBA
01/2022 - 01/2015
2BI 6727IBA
01/2022 - 01/2021
2AntigensIBA
01/2022 - 10/2021
2Sorafenib (BAY 43-9006)FDA Link
11/2021 - 10/2020
2AntibodiesIBA
10/2021 - 06/2014
2Polo-Like Kinase 1IBA
10/2021 - 01/2019
2Messenger RNA (mRNA)IBA
10/2021 - 12/2018
2tributyl phosphate (TBP)IBA
10/2021 - 10/2020
2EstersIBA
01/2021 - 07/2015
2Sulfates (Sulfates, Inorganic)IBA
01/2021 - 10/2016
2Phosphates (Orthophosphate)IBA
01/2021 - 12/2019
2Photosensitizing Agents (Photosensitizers)IBA
01/2021 - 05/2011
2Transferrin Receptors (Transferrin Receptor)IBA
10/2020 - 01/2019

Therapy/Procedure

61Therapeutics
10/2022 - 10/2009
49Drug Therapy (Chemotherapy)
10/2022 - 08/2011
7Immunotherapy
10/2022 - 10/2021
4Intravenous Injections
10/2022 - 12/2016
3Radiotherapy
12/2021 - 11/2019
3RNAi Therapeutics
10/2021 - 12/2018
3Injections
01/2017 - 04/2007
2Molecular Targeted Therapy
11/2021 - 01/2021